Research Interests

Over the years, Dieter Seebach has summarized the results obtained in his research group in review articles. The terms, concepts, techniques, and methodologies introduced and the total syntheses achieved include:

• reactivity umpolung (of carbonyl compounds, amines, imines and nitroolefins) 75, 153, 156, 212, 224
  
• reactivity of nitroaliphatic compounds (Li₂-nitronates, stereoselective nitroaldol additions) 153, 229
• use of organosulfur and – selenium compounds in organic synthesis (PULI No.99) 28, 72, 74, 108, 131
  
• use of microorganism and enzymes as reagents for organic synthesis
• sterically protected, but electronically effective functional groups (SPEEF) 244, 288, 309, 724
• the LiX effect and reactivity of organolithium compounds (PULI No.528) 279, 386
  
• reactivity and selectivity of organotitanium compounds 241, 251, 391, 836, 
• self-regeneration of stereogenic centers (SRS) 576
  
• synthetic applications of electrolysis in enantioselective syntheses
• TADDOLs, a true chiral-auxiliary system (PULI No. 696) 678, 724 , 792
  
• chemistry of fluoro-organic compounds
• immobilization of chiral ligands by dendritic cross-linking in polystyrene and by attachment to controlled pore glass (CPG) 678, 712, 713, 743
• chiral dendrimers 577, 593, 617
• polymers and oligomers of 3-hydroxybutanoate (PHB, OHB) - ion-channel-forming biomacromolecules 480, 595, 640, 720
• chemical, biological and biomedical investigations of peptides consisting of homologated proteinogenic amino acids (β- and γ-peptides )569, 739,763, 767, 768, 775, 787, 815, 819
  
• organocatalysis (OC).
  
• total syntheses of various natural products
• terms:
  pool of chiral building blocks (“chiral pool”) (PULI No. 107)
  the meso-trick 186
  EPC synthesis (enantiomerically pure compounds) 186
  like/unlike specification of the stereochemical course of reactions 233
  the diarylmethanol effect (TADDOL, DIOZ) 678, 724
• discovery of the β-peptide cleaving enzyme BapA (BapA)
  
• General article on the future of Organic Synthesis 421